Research

Research Intern at Rottapel Lab Studying Autophagy Flux

Over this last summer, I worked as a research intern at the Rottapel Lab at the University Health Network . I conducted several experiments under the guidance of Dr. Pallavi Mathur to determine if perturbed lysosome-autophagosome colocalization underlies disturbed autophagy flux in KSR1KO cells. I did cell culture, immunofluorescence, confocal microscopy (25+ hours), image analysis and western blot.

Sophie_Presentation_PDF.pdf

Wastewater treatment in Bangladesh

In a hackathon, my team and I pitched AI-driven inventory management app to predict and prevent antibiotic waste. This was one avenue we found when doing an analysis of the problem.

The other was wastewater treatment. But a big issue here is the cost, which is disincentivizing when unsafe or informal fixes are cheaper and easier to access like dumping directly into water sources.

In the lab at school, I've been exploring various new biotechnologies to treat wastewater. See below for some of these projects and reports.

Generation of Current by Yeast Fermentation

I built a yeast fuel cell which uses yeast and glucose to generate electricity. This is modelled by current research into the use of yeast to generate electricity from cabron compounds in wastewater. Another experiment I plan on running soon is using EDTA to form complexes with heavy metal in wastewater which can help treat the water, connecting to my EE seen below.

Sophie Qian - Internal Assessment Biology Final.pdf

Sophie Q. - Chemistry EE FINAL.pdf

Chemistry Extended Essay: Heavy Metal Inhibition of Catalase

For my Extended Essay, I was drawn to studying biochemistry in an interdisciplinary approach. Specifically, I was eager to study how different metals affect the rate of reaction of hydrogen peroxide decomposition and how the structure of catalase is changed by the allosteric binding.

Biotech Biweekly: A biotechnology article series on Medium.com

Why Wet Lab Validation is Slowing Down AI Antibiotic DiscoveryIn 2019, antibiotic resistance was directly responsible for 1.27 million global deaths and contributed to 4.95 million deaths.

Combatting Antibiotic Resistance: Gene Editing and Phages in the Post-Antibiotic EraPicture a world where antibiotics have lost all effectiveness against bacterial infections. These antimicrobials save an estimated 200,000…

Command + ‘F’ for Cells: How Immunofluorescence Makes Proteins GlowIf you wanted to locate a word in a document, you’d click Command + ‘F’ to highlight every use. If you wanted to locate a protein or…

Are Stem Cells the Future of Regenerative Medicine? TBDWelcome to the extraordinary world of stem cells. Stem cells hold the key to regeneration and endless possibilities. Imagine if you could…

Not All Good Things Last Forever: Antibiotics Might be One of ThemWe’ve all been there. It’s a common thing that antibiotics can get rid of the nasty productive cough, the annoying runny nose, the scratchy…

Phage Therapy: The Solution to Superbug DominationWe’ve all been there — the scratchy throat, the loss of voice, the relentless cough, and the unwelcome fever that disturbs our day and…

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